Association between serum fatty acid composition and innate immune markers in healthy adults
Nutrition Research and Practice
;
: 182-187, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-173777
ABSTRACT
BACKGROUND/OBJECTIVES:
Supplementation with n-3 polyunsaturated fatty acids (PUFAs) has been shown to generally decrease levels of innate immune markers and inflammatory cytokines, but the specific associations between blood levels of PUFAs and those of innate immune markers have not been investigated. Thus, the present study was conducted to test the hypothesis that innate immune markers as well as cytokines are negatively associated with n-3 PUFAs but positively associated with n-6 PUFAs in healthy adults. MATERIALS/METHODS:
One hundred sixty-five healthy Korean adults aged 25-70 years old were included in this cross-sectional study.RESULTS:
Serum levels of n-3 PUFAs, such as 183n3, 205n3, 225n3, and 226n3 were negatively correlated with eosinophil and basophil counts and TNF-α, IFN-γ, IL-4, and IL-10 levels. Multivariate analysis also showed that serum levels of n-3 PUFAs were negatively associated with monocyte, eosinophil, and basophil counts and TNF-α, IFN-γ, IL-4, and IL-12 levels. Additionally, the ratio of 204n6 to 205n3 was positively correlated with eosinophil counts and associated with TNF-α, IFN-γ, and IL-4 levels. However, NK cell activity was not associated with serum fatty acid composition.CONCLUSIONS:
Innate immune markers such as eosinophil, monocyte, and basophil counts were inversely associated with serum levels of n-3 PUFAs, but were positively associated with the 204n6/205n3 ratio in this population.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Basófilos
/
Células Matadoras Naturais
/
Monócitos
/
Biomarcadores
/
Ácidos Graxos Ômega-3
/
Estudos Transversais
/
Análise Multivariada
/
Citocinas
/
Interleucina-4
/
Interleucina-10
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Nutrition Research and Practice
Ano de publicação:
2016
Tipo de documento:
Artigo
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