Sedation with Propofol-Midazolam Combination versus Propofol alone during Spinal Anesthesia: Prospective, Randomized Study / 대한마취과학회지
Korean Journal of Anesthesiology
;
: S10-S13, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-174823
ABSTRACT
BACKGROUND:
Propofol can produce a dose-dependent reduction in blood pressure by providing titratable sedation and rapid recovery. It has been reported that a combination of midazolam and propofol resulted in the significant reduction in the total dose of propofol needed. It was hypothesized that the addition of low-dose midazolam to propofol may provide sufficient sedation without compromising the hemodynamic stability.METHODS:
A total of 40 consecutive patients were randomly assigned to one of two groups (n = 20 each). Group M-P received a bolus of 0.02 mg/kg of midazolam, followed by a propofol infusion with a fixed target concentration of 1.0microgram/ml. Group P received only a propofol infusion with an initial target plasma concentration of 2.5microgram/ml. Subsequent titration of the infusion rates in Group P or the additional midazolam boluses in Group M-P were made in order to maintain a predetermined sedation level.RESULTS:
In Group P, a mean dose of 5.4 +/- 0.7 mg/kg/h propofol was used compared with 2.7 +/- 0.5 mg/kg/h in Group M-P (P<0.0001, plus additional 2.96 +/- 1.8 mg of midazolam). Ephedrine was administered to 15 patients in Group M-P and 17 patients in Group P. Recovery was significantly fast (Group P, 6.8 +/- 2.9 min vs. Group M-P, 9.8 +/- 4.4 min, P<0.05).CONCLUSIONS:
Sedation with propofol plus midazolam requires a lower total dose of propofol compared with propofol alone but has no superior hemodynamic stability. A further study using younger patients and combinations of different doses of each drug will be needed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Pressão Sanguínea
/
Midazolam
/
Propofol
/
Estudos Prospectivos
/
Efedrina
/
Hemodinâmica
/
Hipotensão
/
Raquianestesia
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2005
Tipo de documento:
Artigo
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