Genetic Architecture of Transcription and Chromatin Regulation
Genomics & Informatics
;
: 40-44, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-175052
ABSTRACT
DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic signatures. In particular, chromatin opening is tightly coupled with gene transcription. To understand how these two processes are genetically regulated and associated with each other, we examined the changes of chromatin accessibility and gene expression in response to genetic variation by means of quantitative trait loci mapping. Regulatory patterns commonly observed in yeast and human across different technical platforms and experimental designs suggest a higher genetic complexity of transcription regulation in contrast to a more robust genetic architecture of chromatin regulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Projetos de Pesquisa
/
Fatores de Transcrição
/
Variação Genética
/
Leveduras
/
Cromatina
/
Expressão Gênica
/
Sequências Reguladoras de Ácido Nucleico
/
Análise de Sequência com Séries de Oligonucleotídeos
/
Locos de Características Quantitativas
/
Epigênese Genética
Limite:
Humanos
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2015
Tipo de documento:
Artigo
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