Effects of inhaled corticosteroids on bone mineral density and bone metabolism in children with asthma / 소아과
Korean Journal of Pediatrics
;
: 811-817, 2009.
Artigo
em Coreano
| WPRIM
| ID: wpr-175065
ABSTRACT
PURPOSE:
Inhaled corticosteroids (ICS) are used as first-line agents for the treatment of persistent asthma; however, their use is accompanied by apprehension of potential systemic adverse effects. This study aimed to assess the effects of ICS on bone mineral density (BMD) and bone metabolism in children with asthma.METHODS:
From February 2008 to September 2008, 26 asthmatic children treated with ICS (ICS group), 15 asthmatic children treated with leukotriene receptor antagonist (LTRA) (LTRA group), and 30 healthy children (Control group) were selected from the Korea University Anam Hospital. BMD and serum bone-specific alkaline phosphatase (BALP) levels were measured. The asthmatic children underwent spirometry and methacholine bronchial challenge test.RESULTS:
There were no significant differences in BMD in the lumbar spine (P=0.254) and proximal femur (P=0.297) among the 3 groups. The serum BALP levels were significantly higher in both the ICS (P=0.017) and LTRA (P=0.025) groups than in the Control group. None of the parameters pertaining to ICS use, such as the mean daily dose during the last 6 months, the total cumulative dose, duration of use, and age of commencement of use, showed significant correlations with BMD (P>0.05 for all parameters).CONCLUSIONS:
We demonstrated that a low dose of ICS does not exert any significant adverse effect on bone metabolism in asthmatic children. These findings support the current recommendations with regard to the use of ICS for asthmatic children.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Coluna Vertebral
/
Espirometria
/
Testes de Provocação Brônquica
/
Densidade Óssea
/
Cloreto de Metacolina
/
Corticosteroides
/
Receptores de Leucotrienos
/
Fosfatase Alcalina
/
Fêmur
Tipo de estudo:
Guia de Prática Clínica
Limite:
Criança
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2009
Tipo de documento:
Artigo
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