Gut Microbial Influence and Probiotics on Colorectal Cancer / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 275-284, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-175413
ABSTRACT
The human intestinal microbiota is a community of 10(13)-10(14) microorganisms that harbor in the intestine and normally participate in a symbiotic relationship with human. Technical and conceptual advances have enabled rapid progress in characterizing the taxonomic composition, metabolic capacity and immunomodulatory activity of the human intestinal microbiota. Their collective genome, defined as microbiome, is estimated to contain > or =150 times as many genes as 2.85 billion base pair human genome. The intestinal microbiota and its microbiome form a diverse and complex ecological community that profoundly impact intestinal homeostasis and disease states. It is becoming increasingly evident that the large and complex bacterial population of the large intestine plays an important role in colorectal carcinogenesis. Numerous studies show that gut immunity and inflammation have impact on the development of colorectal cancer. Additionally, bacteria have been linked to colorectal cancer by the production of toxic and genotoxic bacterial metabolite. In this review, we discuss the multifactorial role of intestinal microbiota in colorectal cancer and role for probiotics in the prevention of colorectal cancer.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Toxinas Biológicas
/
Bacteroides
/
Neoplasias Colorretais
/
Espécies Reativas de Oxigênio
/
Probióticos
/
Metagenoma
/
Ácidos Graxos não Esterificados
/
Sulfeto de Hidrogênio
/
Mucosa Intestinal
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2012
Tipo de documento:
Artigo
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