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Effect of Gd-DTPA on Diffusion in Canine Brain with Hyperacute Stroke
Journal of the Korean Society of Magnetic Resonance in Medicine ; : 158-165, 2002.
Artigo em Coreano | WPRIM | ID: wpr-175541
ABSTRACT

PURPOSE:

To evaluate the effect of Gd-DTPA on signal intensity of diffusion-weighted magnetic resonance (MR) image and apparent diffuse coefficient (ADC) in dog brain with hyperacute stroke. MATERIALS AND

METHODS:

Experimental canine model of hyperacute cerebral infarction was made by selective intraarterial embolization with particulate embolic material. Diffusion-weighted MR imaging was performed in five dogs at 1 hour after the embolization of internal carotid artery. After intravenous bolus injection of Gd-DTPA, additional 11 diffusion-weighted MR images were serially obtained from 2 minutes to 90 minutes after injection in each dog. The author evaluated findings of hyperacute cerebral infarction on diffusion-weighted MR imaging, and calculated mean signal intensity and mean ADC in infarcted region and contralateral normal region. Statistical analysis of mean signal intensity, mean ADC and contrast-noise ratio before and after Gd-DTPA injection was performed.

RESULTS:

Hyperacute cerebral infarction developed in all five dogs on diffusion-weighted MR images obtained 1 hour after embolization. The area of hyperacute infarction had steady increase in signal intensity on diffusion-weighted MR image and decrease in ADC. In normal perfusion area, decrease in signal intensity was observed at 2 minutes the Gd-DTPA injection, whereas ADC did not changed.

CONCLUSION:

Intravenous injection of Gd-DTPA had no influence on ADC in both hyperacute infarction and normally perfused area, but caused initial transient signal reduction in normally perfused area on diffusion-weighted MR image due to susceptibility effect of Gd-DTPA. It is important to calculate ADC in evaluating the effect of diffusion after injection of Gd-DTPA.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Encéfalo / Imageamento por Ressonância Magnética / Artéria Carótida Interna / Infarto Cerebral / Gadolínio DTPA / Acidente Vascular Cerebral / Difusão / Infarto / Injeções Intravenosas Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Coreano Revista: Journal of the Korean Society of Magnetic Resonance in Medicine Ano de publicação: 2002 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Perfusão / Encéfalo / Imageamento por Ressonância Magnética / Artéria Carótida Interna / Infarto Cerebral / Gadolínio DTPA / Acidente Vascular Cerebral / Difusão / Infarto / Injeções Intravenosas Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Coreano Revista: Journal of the Korean Society of Magnetic Resonance in Medicine Ano de publicação: 2002 Tipo de documento: Artigo