In Vitro Effects of Rabeprazole on Human Pylorus Tone
Journal of Neurogastroenterology and Motility
;
: 217-221, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-176182
ABSTRACT
BACKGROUND/AIMS:
It has been reported that proton pump inhibitors induce relaxation in different types of smooth muscles. The aim of this study is to investigate in vitro effects of proton pump inhibitors on human pylorus muscle.METHODS:
Pyloric sphincters were studied in 10 patients who were operated for stomach cancer. In isolated organ bath, control and response to rabeprazole were recorded following contraction with carbachol. During the treatment experiment, while distilled water was applied during the control experiment in every 5 minutes, rabeprazole was administered in every 5 minutes at doses of 10-6, 10-5, 10-4, and 10-3 M respectively. Contraction frequencies, maximum contraction values and muscle tones were measured.RESULTS:
The contraction frequencies in the control group were greater than the rabeprazole group in the second, third and fourth intervals while the maximum contraction values in the rabeprazole group were lower in the fourth interval. Even though muscles tones were not different in both groups during all intervals, it was remarkable that the muscle tone was significantly decreased in the rabeprazole group during the fourth interval compared to the first and second intervals.CONCLUSIONS:
In the present study, high doses of rabeprazole reduced contraction frequencies, maximum contraction values, and muscle tone of human pylorus.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piloro
/
Relaxamento
/
Neoplasias Gástricas
/
Banhos
/
Carbacol
/
Água
/
Inibidores da Bomba de Prótons
/
Rabeprazol
/
Músculo Liso
/
Tono Muscular
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Neurogastroenterology and Motility
Ano de publicação:
2015
Tipo de documento:
Artigo
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