Attenuation of endothelial relaxation in umbilical arteries from preeclampsia patients / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1043-1050, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-176769
ABSTRACT
OBJECTIVES AND METHODS:
To directly examine the function of the endothelial cell(EC) and smooth muscle cell in umbilical arteries acquired from preeclampsia patients between June 1998 to November 1999, using a conventional tension measurement and bioassay experiment.RESULTS:
Relaxation responses to EC-dependent relaxing agents including bradykinin and A23187 in human umbilical artery rings were significantly decreased in preeclampsia(p<0.01). Relaxation responses to EC-independent agents(SNP and SNAP) were also inhibited in umbilical artery rings acquired from preeclampsia patients(p<0.01). To test the change of endothelial cell function in preeclampsia without involvement of smooth muscle dysfunction, we used human umbilical artery and rabbit femoral artery as a donor and detector, respectively, in bioassay experiment. Relaxation responses to EC-dependent agents(A23187 and bradykinin) showed similar results to conventional tension measurement (p<0.01). Relaxation responses to 8-bromo-cGMP in human umbilical artery rings were also significantly decreased in preeclampsia(p<0.01).CONCLUSIONS:
It can be concluded that increased vascular resistance in preeclampsia is not only due to the disturbance of endothelial function, but also to smooth muscle dysfunction.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pré-Eclâmpsia
/
Relaxamento
/
Doadores de Tecidos
/
Artérias Umbilicais
/
Resistência Vascular
/
Bioensaio
/
Bradicinina
/
Calcimicina
/
Miócitos de Músculo Liso
/
Células Endoteliais
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2000
Tipo de documento:
Artigo
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