The effect of Vitamin D(3)addition on bone mineral density in postmenopausal hormone replacement / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 992-997, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-176777
ABSTRACT
OBJECTIVE:
To determine the effect of the addition of Vit. D3 (1,25-Dihydroxychole calciferol D3) to the conventional postmenopausal hormone replacement therapy on bone mineral density(BMD)DESIGN:
A 2-year retrospective , randomized studySetting:
Department of Obstetrics and Gynecology of Catholic university hospital Patients 388 postmenopausal women were recruited and divided into 5 groups according to treatment regimen; A conjugated estrogens only treated group(n=146), B conjugated estrogens and progesterone treated group(n=103), C conjugated estrogens and Vit.D3 treated group (n=36), D conjugated estrogens, progesterone and Vit.D3 treated group (n=41), E control group (n=60).METHODS:
The bone mineral density of the lumbar spines and femoral neck were determined by dual-energy X-ray absorptiometry(DEXA) every 2 years. STATISTICS The difference between before and after treatment was determined by paired t-test. The comparison among the groups were determined by one way ANOVA test and student's t-test.RESULTS:
The addition of progesterone to estrogen showed insignificant increase in the lumbar and femoral neck BMD. The addition of Vit. D3 compared with conventional hormone replacement therapy insignificantly influened bone density in women with initially normal BMD, but definitely increase in women with initially osteopenic and osteoporotic BMD of femoral neck rather than lumar spine(p<0.05).CONCLUSIONS:
The use of Vit. D3 combined with postmenopausal estrogen replacement effects the increase of BMD in low bone density than normal bone density, especially femoral neck.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Progesterona
/
Coluna Vertebral
/
Vitaminas
/
Densidade Óssea
/
Terapia de Reposição de Estrogênios
/
Estudos Retrospectivos
/
Estrogênios Conjugados (USP)
/
Terapia de Reposição Hormonal
/
Estrogênios
/
Colo do Fêmur
Tipo de estudo:
Estudo observacional
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2000
Tipo de documento:
Artigo
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