Response of Leptomeningeal Dissemination of Anaplastic Glioma to Temozolomide: Experience of Two Cases
Brain Tumor Research and Treatment
; : 99-104, 2017.
Article
em En
| WPRIM
| ID: wpr-176896
Biblioteca responsável:
WPRO
ABSTRACT
The incidence of leptomeningeal dissemination (LMD) of anaplastic glioma has been increasing. LMD can be observed at the time of initial presentation or the time of recurrence. As a result of both rarity and unusual presentation, a standard therapy has not yet been suggested. In contrast to leptomeningeal carcinomatosis for systemic solid cancers, a relatively prolonged survival is observed in some patients with LMD of anaplastic gliomas. Treatment modalities include whole craniospinal irradiation, intra-cerebrospinal fluid (CSF) chemotherapy, and systemic chemotherapy. In some cases, response to temozolomide (TMZ), with or without combined radiation has been reported. Here, we report two cases of LMD of an anaplastic glioma. In one case LMD presented at the time of diagnosis, and in the other at the time of recurrence after radiation. CSF cytology was positive in both cases, and persisted in spite of intrathecal methotrexate chemotherapy. Later, TMZ was prescribed for progressing brain parenchymal lesions, and both radiological and cytological responses were obtained after oral TMZ treatment.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Recidiva
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Encéfalo
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Líquido Cefalorraquidiano
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Metotrexato
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Incidência
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Diagnóstico
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Tratamento Farmacológico
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Carcinomatose Meníngea
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Radiação Cranioespinal
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Glioma
Tipo de estudo:
Diagnostic_studies
/
Incidence_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Brain Tumor Research and Treatment
Ano de publicação:
2017
Tipo de documento:
Article