Regulation of NFATc1 in Osteoclast Differentiation
Journal of Bone Metabolism
;
: 233-241, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-177280
ABSTRACT
Osteoclasts are unique cells that degrade the bone matrix. These large multinucleated cells differentiate from the monocyte/macrophage lineage upon stimulation by two essential cytokines, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B (NF-kappaB) ligand (RANKL). Activation of transcription factors such as microphthalmia transcription factor (MITF), c-Fos, NF-kappaB, and nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation. In particular, NFATc1 plays the role of a master transcription regulator of osteoclast differentiation. To date, several mechanisms, including transcription, methylation, ubiquitination, acetylation, and non-coding RNAs, have been shown to regulate expression and activation of NFATc1. In this review, we have summarized the various mechanisms that control NFATc1 regulation during osteoclast differentiation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoclastos
/
Acetilação
/
Fatores de Transcrição
/
Matriz Óssea
/
Linfócitos T
/
Regulação da Expressão Gênica
/
Microftalmia
/
Citocinas
/
Fator Estimulador de Colônias de Macrófagos
/
NF-kappa B
Idioma:
Inglês
Revista:
Journal of Bone Metabolism
Ano de publicação:
2014
Tipo de documento:
Artigo
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