Analysis of Operative Results in Pituitary Adenoma

ABSTRACT

The authors have reported on 34 patients with pituitary adenoma who underwent surgical treatment. The preoperative and postoperative clinical manifestations, size, and extension of tumor, therapeutic modalities and changes of endocrinological symptoms and hormonal values. In a series of 34 adenomas, 7(25%) were non-secreting and 27(79%) produced a hypersecretion syndrome; human growth hormone(5), prolactin(17), mixed GH and PRL type(3), corticotropic adenoma(2). The principal symptoms were endocrinological symptoms(74%), visual disturbance(59%) and headache(50%) on a admission. Vision improved in 90% of the patients. Normal menstruation returned in 35.3% of the prolactinoma. Endocrine cure was possible in 24% of prolactin-secreting and 40% of GH-secreting and 33% of mixed GH, PRL adenomas and not improved in corticotropic adenomas. The mortality rate was 0.6%. Postoperative radiation therapy appeared to play a greater role.