Annotation of Genes Having Candidate Somatic Mutations in Acute Myeloid Leukemia with Whole-Exome Sequencing Using Concept Lattice Analysis
Genomics & Informatics
;
: 38-45, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-177966
ABSTRACT
In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oncogenes
/
Análise Mutacional de DNA
/
Leucemia Mieloide Aguda
/
Genes Supressores
/
Genoma
/
Análise de Sequência de DNA
Idioma:
Inglês
Revista:
Genomics & Informatics
Ano de publicação:
2013
Tipo de documento:
Artigo
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