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Altered Transendothelial Transport of Hormones as a Contributor to Diabetes
Diabetes & Metabolism Journal ; : 92-99, 2014.
Artigo em Inglês | WPRIM | ID: wpr-17799
ABSTRACT
The vascular endothelium is a dynamic structure responsible for the separation and regulated movement of biological material between circulation and interstitial fluid. Hormones and nutrients can move across the endothelium either via a transcellular or paracellular route. Transcellular endothelial transport is well understood and broadly acknowledged to play an important role in the normal and abnormal physiology of endothelial function. However, less is known about the role of the paracellular route. Although the concept of endothelial dysfunction in diabetes is now widely accepted, we suggest that alterations in paracellular transport should be studied in greater detail and incorporated into this model. In this review we provide an overview of endothelial paracellular permeability and discuss its potential importance in contributing to the development of diabetes and associated complications. Accordingly, we also contend that if better understood, altered endothelial paracellular permeability could be considered as a potential therapeutic target for diabetes.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Permeabilidade / Fisiologia / Endotélio Vascular / Junções Íntimas / Junções Aderentes / Líquido Extracelular / Endotélio / Adiponectina / Insulina Idioma: Inglês Revista: Diabetes & Metabolism Journal Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Permeabilidade / Fisiologia / Endotélio Vascular / Junções Íntimas / Junções Aderentes / Líquido Extracelular / Endotélio / Adiponectina / Insulina Idioma: Inglês Revista: Diabetes & Metabolism Journal Ano de publicação: 2014 Tipo de documento: Artigo