Association between Macrophage Migration Inhibitory Factor Gene Polymorphism and Rheumatoid Arthritis / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 108-115, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-178148
ABSTRACT
OBJECTIVE:
Rheumatoid arthritis (RA) is characterized by the interaction of multiple mediators, especially cytokines. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and has been shown to be involved in RA. This study explored the association of the MIF gene polymorphism with RA in Korean.METHODS:
114 patients with RA, and 114 age and gender matched healthy controls were studied. Patients and controls were genotyped for a single nucleotide polymorphism (SNP) in the 5'-flanking region at position -173 of the MIF gene.RESULTS:
No significant differences in MIF gene polymorphism were observed in RA compared to healthy controls. No association with disease severity was detected for the MIF gene polymorphism.CONCLUSION:
MIF -173 G/C polymorphism did not appear to be associated with genetic susceptibility and disease severity in Korean RA patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite Reumatoide
/
Citocinas
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Macrófagos
Limite:
Humanos
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
2005
Tipo de documento:
Artigo
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