Psychosocial stress and changes in estimated glomerular filtration rate among adults with diabetes mellitus
Kidney Research and Clinical Practice
;
: 146-153, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-179039
ABSTRACT
BACKGROUND:
Psychosocial stress has been hypothesized to impact renal changes, but this hypothesis has not been adequately tested. The aim of this study was to examine the relationship between psychosocial stress and estimated glomerular filtration rate (eGFR) and to examine other predictors of eGFR changes among persons with diabetes mellitus (DM).METHODS:
Data from a survey conducted in 2005 by a major health maintenance organization located in the southeastern part of the United States, linked to patients' clinical and pharmacy records (n=575) from 2005 to 2008, was used. Study participants were working adults aged 25-59 years, diagnosed with DM but without advanced microvascular or macrovascular complications. eGFR was estimated using the Modification of Diet in Renal Disease equation. A latent psychosocial stress variable was created from five psychosocial stress subscales. Using a growth factor model in a structural equation framework, we estimated the association between psychosocial stress and eGFR while controlling for important covariates.RESULTS:
The psychosocial stress variable was not directly associated with eGFR in the final model. Factors found to be associated with changes in eGFR were age, race, insulin use, and mean arterial pressure.CONCLUSION:
Among fairly healthy DM patients, we did not find any evidence of a direct association between psychosocial stress and eGFR changes after controlling for important covariates. Predictors of eGFR change in our population included age, race, insulin use, and mean arterial pressure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmácia
/
Estados Unidos
/
Sistemas Pré-Pagos de Saúde
/
Grupos Raciais
/
Diabetes Mellitus
/
Dieta
/
Pressão Arterial
/
Taxa de Filtração Glomerular
/
Insulina
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Humanos
País/Região como assunto:
América do Norte
Idioma:
Inglês
Revista:
Kidney Research and Clinical Practice
Ano de publicação:
2015
Tipo de documento:
Artigo
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