Apoptosis and Cell Proliferation in Gastric Adenoma and Adenocarcinoma
Journal of the Korean Gastric Cancer Association
;
: 91-96, 2006.
Artigo
em Coreano
| WPRIM
| ID: wpr-179512
ABSTRACT
PURPOSE:
Cancer is a genetic disease caused by alterations in key regulators of cell growth and cell turnover. We investigated apoptotic cell death and cell proliferation in gastric adenomas and adenocarcinomas. MATERIALS ANDMETHODS:
The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method and immunohistochemistry for Ki-67 were performed, using paraffin-embedded tissues of 41 gastric adenomas and 100 gastric adenocarcinomas. These results were compared with histopathologic parameters.RESULTS:
The Ki-67 labelling index was higher in adenocarcinomas than in adenomas and the apoptotic index was higher in adenomas than in adenocarcinomas. There were no significant difference between the apoptotic index/Ki-67 labelling index and clinicopathological parameters.CONCLUSION:
We propose that cell proliferation is more closely associated with gastric adenocarcinomas than apoptosis is, but that neither has any clinical significance as a prognostic factor in gastric adenocarcinomas.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imuno-Histoquímica
/
Adenocarcinoma
/
Adenoma
/
Morte Celular
/
Apoptose
/
Proliferação de Células
Tipo de estudo:
Estudo prognóstico
Idioma:
Coreano
Revista:
Journal of the Korean Gastric Cancer Association
Ano de publicação:
2006
Tipo de documento:
Artigo
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