Chromosomal gains and losses in primary ovarian carcinomas by comparative genomic hybridization / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 38-43, 2003.
Artigo
em Coreano
| WPRIM
| ID: wpr-179663
ABSTRACT
OBJECTIVE:
Comparative genomic hybridization was performed to evaluate DNA sequence copy number changes in human ovarian carcinomas from paraffin-embedded tissue blocks. PATIENTS ANDMETHODS:
DNA from 20 cases of primary ovarian carcinomas underwent comparative genomic hybridization to evaluate the extent of genetic gains or losses in a test sample.RESULTS:
In thirteen cases of 20 samples, varying degree of genetic imbalances was observed. Of the remaining 7 cases, two revealed normal, five failed to yield a result. Most common genetic imbalances are 8q22.2-q24 site amplification and 12p site amplification, where c-myc gene and k-ras gene respectively are included. Second most common site of genetic imbalance is 7p21-pter site deletion.CONCLUSION:
Our results have shown many chromosomal alterations in human ovarian carcinomas, and these sites are known previously as oncogene or tumor-suppression gene, and some sites are not known specific cancer associated sites. Our data can be useful for screening chromosomal changes and molecular mechanism of human ovarian carcinogenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oncogenes
/
Neoplasias Ovarianas
/
DNA
/
Sequência de Bases
/
Programas de Rastreamento
/
Genes myc
/
Genes ras
/
Hibridização Genômica Comparativa
/
Carcinogênese
Tipo de estudo:
Estudo de rastreamento
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2003
Tipo de documento:
Artigo
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