Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts
Allergy, Asthma & Immunology Research
;
: 288-295, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-17987
ABSTRACT
Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have revealed unanticipated insights into the regulation of cys-LT synthesis, the function of the cys-LTs in innate and adaptive immunity and human disease, and the identification of a new receptor for the cys-LTs. This review highlights these studies and summarizes their potential pathobiologic and therapeutic implications.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Asma
/
Araquidonato 5-Lipoxigenase
/
Leucotrienos
/
Células Clonais
/
Ácido Araquidônico
/
Mediadores da Inflamação
/
Clonagem de Organismos
/
Imunidade Adaptativa
Limite:
Humanos
Idioma:
Inglês
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2014
Tipo de documento:
Artigo
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