Erythropoietin and autoimmune neuroinflammation: lessons from experimental autoimmune encephalomyelitis and experimental autoimmune neuritis / 대한해부학회지
Anatomy & Cell Biology
;
: 215-220, 2012.
Artigo
em Inglês
| WPRIM
| ID: wpr-179888
ABSTRACT
Erythropoietin (EPO) is known to have numerous biological functions. While its primary function is during haematopoiesis, recent studies have shown that EPO plays important role in cytoprotection, immunomodulation, and antiapoptosis. These secondary functions of EPO are integral to tissue protection following hypoxic injury, ischemia-reperfusion injury, and spinal cord injury in the central nervous system. This review focuses on experimental evidence documenting the neuroprotective effects of EPO in organ-specific autoimmune nervous system disorders such as experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune neuritis (EAN). In addition, the immunomodulatory role of EPO in the pathogenesis of EAE and EAN animal models of human multiple sclerosis and Guillain-Barre syndrome, respectively, will be discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doenças Autoimunes
/
Traumatismos da Medula Espinal
/
Traumatismo por Reperfusão
/
Sistema Nervoso Central
/
Eritropoetina
/
Fármacos Neuroprotetores
/
Citoproteção
/
Síndrome de Guillain-Barré
/
Modelos Animais
/
Encefalomielite
Limite:
Humanos
Idioma:
Inglês
Revista:
Anatomy & Cell Biology
Ano de publicação:
2012
Tipo de documento:
Artigo
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