Spinal Gap Junction Channels in Neuropathic Pain
The Korean Journal of Pain
;
: 231-235, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-180009
ABSTRACT
Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and activity of gap junction channels in the spinal cord are involved in the development of neuropathic pain. Thus, this review briefly summarizes evidence that regulation of the expression, coupling, and activity of spinal gap junction channels modulates pain signals in neuropathic pain states induced by peripheral nerve or spinal cord injury. We particularly focus on connexin 43 and pannexin 1 because their regulation vastly attenuates symptoms of neuropathic pain. We hope that the study of gap junction channels eventually leads to the development of a suitable treatment tool for patients with neuropathic pain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Nervos Periféricos
/
Medula Espinal
/
Traumatismos da Medula Espinal
/
Neuroglia
/
Junções Comunicantes
/
Conexina 43
/
Dor Crônica
/
Esperança
/
Neuralgia
Limite:
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Pain
Ano de publicação:
2015
Tipo de documento:
Artigo
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