Glutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 205-211, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-18019
ABSTRACT
PURPOSE:
To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used for the genotyping analyses, and statistical evaluation was performed by an unconditional logistic regression model.RESULTS:
No association was observed in the study subjects, or the premenopausal women group with GSTP1 Val allele. However, postmenopausal women with GSTP1 Val allele had a reduced risk of breast cancer (OR=0.3, 95% CI=0.1~0.7). When the data were stratified, by the known risk factors of breast cancer, a significant interaction was observed between the GSTP1 genotype and alcohol consumption (p for interaction = 0.01); women with GSTP1 Val allele, that drank regularly, had a 3.0-fold increased risk of breast cancer (95% CI=1.1~7.9), whereas women with GSTP1 Val allele, that never drink, had protective effects (OR=0.4, 95% CI=0.2~0.8).CONCLUSION:
Our findings suggest that GSTP1 Ile105Val polymorphism influences the individual susceptibility to breast cancer, and that this effect may be modified by alcohol consumption.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Mama
/
Neoplasias da Mama
/
Consumo de Bebidas Alcoólicas
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Reação em Cadeia da Polimerase
/
Fatores de Risco
/
Alelos
/
Genótipo
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Cancer Research and Treatment
Ano de publicação:
2002
Tipo de documento:
Artigo
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