Cognition and Visit-to-Visit Variability of Blood Pressure and Heart Rate in De Novo Patients with Parkinson's Disease
Journal of Movement Disorders
; : 144-151, 2016.
Article
em En
| WPRIM
| ID: wpr-180367
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE: We sought to identify whether the characteristics of long-term visit-to-visit blood pressure (BP) and heart rate (HR) are related to baseline cognitive profiles in, Parkinson’s disease (PD). METHODS: We selected drug-naïve PD patients who visited our hospital at least 10 times with a baseline assessment of the Seoul neuropsychological battery. BP and HR were measured at each visit, and the variability of the systolic BP/diastolic BP (DBP) and HR was derived from the parameters of serial 10 office visits. Mild cognitive impairment (MCI) in PD patients was determined according to the proposed criteria with a cut-off value of z-score ≤ -2. RESULTS: Forty-seven patients with PD (mean follow-up duration = 22.3 months) were enrolled in the study. Compared with non-MCI PD patients, MCI PD patients revealed a significant increase in HR and/or variability in DBP. CONCLUSION: This exploratory study showed that baseline cognition in drug-naïve PD patients might be related to the visit-to-visit variability of DBP and/or HR.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Visita a Consultório Médico
/
Doença de Parkinson
/
Pressão Sanguínea
/
Seguimentos
/
Cognição
/
Disfunção Cognitiva
/
Seul
/
Coração
/
Frequência Cardíaca
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Journal of Movement Disorders
Ano de publicação:
2016
Tipo de documento:
Article