Two Cases of Stevens-Johnson Syndrome Caused by Systemic Corticosteroids / 대한피부과학회지

ABSTRACT

Stevens-Johnson syndrome (SJS) is a fatal, acute, hypersensitivity reaction which is associated with certain drugs. The disease has often been managed by systemic corticosteroids. However, there have been a few reports of SJS caused by systemic corticosteroids in Western countries. We herein present two cases of SJS related to deflazacort and betamethasone sodium phosphate. It is worth mentioning that corticosteroids might be offending drugs for SJS. Due to the difficulty in predicting a cross-reaction between corticosteroids and also the existence of concomitant allergies to other corticosteroids, we should consider an alternative strategy such as intravenous immunoglobulin-G in patients with SJS caused by systemic corticosteroids.