Association Study of a Serotonin Receptor 2A Gene -1438A/G Polymorphism and Anxiety-Related Traits
Psychiatry Investigation
;
: 244-246, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-180646
ABSTRACT
OBJECTIVE:
The aim of this study was to investigate the relationship between the -1438A/G polymorphism of serotonin receptor 2A (5HTR2A) and anxiety-related traits in Korean adolescent females.METHODS:
A total of 174 Korean adolescent females were tested for the -1438A/G polymorphism of 5HTR2A using polymerase chain reaction (PCR)-based methods. Anxiety-related traits were evaluated using the Anxiety Sensitivity Index (ASI) and the trait form of the Spielberg State-Trait Anxiety Inventory (T-STAI).RESULTS:
There was no difference between the genotypes with respect to scores pertaining to anxiety-related traits. Although the G allele carriers (GG or AG genotype) scored lower on the psychological subscale of the ASI (4.76+/-3.00 vs 5.98+/-4.00, p=0.038), this difference was not significant after Bonferroni correction.CONCLUSION:
These findings suggest that the -1438A/G polymorphism of 5HTR2A might not be associated with anxiety sensitivity or trait anxiety.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ansiedade
/
Serotonina
/
Reação em Cadeia da Polimerase
/
Receptor 5-HT2A de Serotonina
/
Alelos
/
Genótipo
Limite:
Adolescente
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Psychiatry Investigation
Ano de publicação:
2008
Tipo de documento:
Artigo
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