A Neuromedin B Receptor Blockade Inhibits the Growth of Human Oral Cancer Cells
International Journal of Oral Biology
;
: 1-7, 2014.
Artigo
em Coreano
| WPRIM
| ID: wpr-180774
ABSTRACT
Neuromedin B (NMB) acts as a growth factor or a morphogen and plays a role in cancer progression. Indeed, the NMB receptor (NMB-R) is overexpressed in different types of tumors. In our current study, we investigated the involvement of NMB-R in the proliferation of oral cancer cells. Human oral squamous cell carcinoma (SCC) and human oral cancer cells, SCC-25 cells were found to be NMB-R-positive. The NMB-R antagonist PD168368 inhibited the proliferation of SCC-25 cells and reduced their colony formation capacity. We also found that PD168368 induced the cell cycle arrest and apoptosis of SCC-25 cells in a dose-/time-dependent manner. Overall, this antitumor activity of PD168368 in human oral cancer cells suggests that NMB-R is a potential target for the future prevention and treatment of human cancers.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Apoptose
/
Receptores da Bombesina
/
Pontos de Checagem do Ciclo Celular
Limite:
Humanos
Idioma:
Coreano
Revista:
International Journal of Oral Biology
Ano de publicação:
2014
Tipo de documento:
Artigo
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