Bone Mineral Density Changes after Orchiectomy using a Scrotal Approach in Rats
Korean Journal of Spine
;
: 55-59, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-181090
ABSTRACT
OBJECTIVE:
To investigate a suitable animal model for studies of male osteoporosis. Osteoporosis has a particularly high incidence in postmenopausal women, resulting in a substantial amount of research with respect to this disease in women. However, research on osteoporosis in men is still lacking.METHODS:
Twenty 10-week-old male Sprague Dawley rats were used in this study, including 4 rats used to establish a baseline bone mineral density (BMD). The other 16 rats were divided into two groups a sham surgery group (n=8), which underwent a sham operation, and an orchiectomized rat group (OCX) (n=8), which underwent bilateral OCX at 10 weeks of age. Bone mineral density was measured in 4 rats from both the sham surgery group and the OCX group 8 weeks after the surgery, while BMD in the remainder of the rats was measured 10 weeks post-surgery.RESULTS:
Femoral BMD at 8 weeks post-surgery was found to be significantly lower in the OCX group compared to the sham group; a finding that was also similar 10 weeks post-surgery.CONCLUSION:
8 weeks after undergoing orchiectomy performed via a scrotal, white rats are a suitable model for studies of male osteoporosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoporose
/
Orquiectomia
/
Densidade Óssea
/
Incidência
/
Ratos Sprague-Dawley
/
Neoplasia Endócrina Múltipla Tipo 1
/
Modelos Animais
/
Fêmur
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Animais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Korean Journal of Spine
Ano de publicação:
2015
Tipo de documento:
Artigo
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