Molecular targeting for treatment of advanced hepatocellular carcinoma / 대한간학회지
The Korean Journal of Hepatology
;
: 299-308, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-181188
ABSTRACT
Hepatocellular carcinoma (HCC) is a major global health problem, which has a grave morbidity and mortality. Over the past few decades, no effective systemic therapeutic modalities have been established for patients with the unresectable HCC in advanced stage. Sorafenib is a small molecule that blocks cancer cell proliferation by targeting the intracellular signaling pathway at the level of Raf-1 and B-Raf serine-threonine kinases, and exerts an anti-angiogenic effect by targeting the vascular endothelial growth factor receptor-1, 2 and 3, and platelet-derived growth factor receptor-beta tyrosine kinases. Recently, two clinical successful applications, SHARP and Asia-Pacific trial, of multikinase inhibitor sorafenib represent a significant advance in the treatment of advanced HCC patients without a curative chance. However, because the results of clinical trials show diverse responses in a subset of HCC patients, a molecular classification of HCC through the excavation of specific biomarkers related to its biological behavior is necessary for sorting HCC patients to each group with a biological homogeneity, ultimately leading to the most suitable individualization of molecular targeted therapy in HCC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piridinas
/
Benzenossulfonatos
/
Transdução de Sinais
/
Receptores do Fator de Crescimento Derivado de Plaquetas
/
Carcinoma Hepatocelular
/
Proteínas Proto-Oncogênicas c-raf
/
Receptores de Fatores de Crescimento do Endotélio Vascular
/
Proteínas Proto-Oncogênicas B-raf
/
Neoplasias Hepáticas
/
Neovascularização Patológica
Limite:
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2009
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS