A Case of Vancomycin Induced Delayed Hypersensitivity Reaction: A Patient of Bacterial Endocarditis with Systemic Emboli / 대한내과학회지

ABSTRACT

Vancomycin, one of glycopeptide antibiotics, has been used in recent years with the emergence of methicillin- resistant staphylococcus aureus (MRSA), coagulase negative staphylococci (CNS) as important hospital pathogens. A 75 years male patient receiving vancomycin 1g intravenously as twice daily dose for treatment of bacterial endocarditis, suffered from high fever, generalized diffuse erythematous maculopapular eruption, itching and eosinophilia, during course of 16th day of vancomycin therapy for treatment of bacterial endocarditis. This delayed hypersensitivity reaction was resolved with discontinuation of the drug and treatment with antihistamine. Awareness of vancomycin associated delayed hypersensitivity reactions is necessary during the treatment in patients with long-term infusion of vancomyin despite of delayed cutaneous reaction and fever associated with vancomycin therapy is not common.