A Case of Recurrent Mantle Cell Lymphoma in the form of Intestinal Lymphomatous Polyposis / 대한내과학회지

ABSTRACT

Mantle cell lymphoma (MCL) is a recently redefined category of malignant lymphoma that has been indivisualized under different names, because of classifications, such as the Working Formulation, fail to recognize it. In the Working Formulation, MCL is classified as diffuse small cleaved cell lymphoma most frequently. Immunophenotyping has a tremendous value in diagnosis of MCL and adds the accuracy of diagnosis. It more commonly arises in peripheral lymph nodes, but in colon, usually presents as a diffuse infiltration, known as multiple lymphomatous polyposis and lymphomatous polyposis can be regarded as the intestinal form of MCL. We recently experienced a case of recurrent MCL presented with a peculiar feature of intestinal lymphomatous polyposis in a 57-year old male patient. He had been diagnosed diffuse small cleaved cell lymphoma of tonsil and treated by CHOP chemotherapy. He developed a recurrence in stomach, colon, liver, spleen and bone marrow after 16 months in complete remission. We could confirm the previously diagnosed lymphoma of tonsil as MCL by adding immunophenotyping with cyclin D1 and CD5. He received salvage chemotherapy and responded partially. We report a case of MCL relapse in the form of intestinal lymphomatous polyposis and literatures are reviewed.