Serotonin transporter mRNA expression in the dorsal raphe nucleus of a tumor bearing mouse
Experimental & Molecular Medicine
;
: 65-69, 2005.
Artigo
em Inglês
| WPRIM
| ID: wpr-18129
ABSTRACT
This study was conducted to determine if an oral squamous cell carcinoma alters mRNA expression of serotonin transporter (5-HTT) in the central nervous system. KB cell line derived from a human oral squamous cell carcinoma was inoculated into nude mice, and mRNA expression level of 5-HTT in the dorsal raphe nucleus (DRN) was examined by in situ hybridization when the tumor mass reached to -10% of total body weight. Plasma leptin levels were determined by radioimmunoassay method using a commercial kit. 5-HTT mRNA level was significantly decreased in the DRN of tumor bearing mice, compared to the age-matching non-tumor control. Plasma leptin level decreased concomitantly in tumor bearing mice. These results suggest that oral carcinoma may suppress 5-HTT gene expression in the central nervous system, perhaps in relation with decreased plasma leptin level.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteínas de Membrana Transportadoras
/
Peso Corporal
/
RNA Mensageiro
/
Neoplasias Bucais
/
Radioimunoensaio
/
Núcleos da Rafe
/
Glicoproteínas de Membrana
/
Carcinoma de Células Escamosas
/
Serotonina
/
Regulação Neoplásica da Expressão Gênica
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Experimental & Molecular Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
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