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Chamnamul Pimpinella brachycarpa (Kom.) Nakai ameliorates hyperglycemia and improves antioxidant status in mice fed a high-fat, high-sucrose diet
Nutrition Research and Practice ; : 446-452, 2013.
Artigo em Inglês | WPRIM | ID: wpr-181572
ABSTRACT
Chronic consumption of a high-fat, high-sucrose (HFHS) diet increases insulin resistance and results in type 2 diabetes mellitus in C57BL/6J mice. Hyperglycemia in diabetics increases oxidative stress, which is associated with a high risk of diabetic complications. The purpose of this study was to examine the hypoglycemic and antioxidant effects of chamnamul [Pimpinella brachycarpa (Kom.) Nakai] in an animal model of type 2 diabetes. The alpha-glucosidase inhibitory activity of a 70% ethanol extract of chamnamul was measured in vitro. Five-week-old male C57BL/6J mice were fed a basal or HFHS diet with or without a 70% ethanol extract of chamnamul at a 0.5% level of the diet for 12 weeks after 1 week of adaptation. After sacrifice, serum glucose, insulin, adiponectin, and lipid profiles, and lipid peroxidation of the liver were determined. Homeostasis model assessment for insulin resistance (HOMA-IR) was determined. Chamnamul extract inhibited alpha-glucosidase by 26.7%, which was 78.3% the strength of inhibition by acarbose at a concentration of 0.5 mg/mL. Serum glucose, insulin, and cholesterol levels, as well as HOMA-IR values, were significantly lower in the chamnamul group than in the HFHS group. Chamnamul extract significantly decreased the level of thiobarbituric acid reactive substances and increased the activities of superoxide dismutase, catalase, and glutathione peroxidase in the liver compared with the HFHS group. These findings suggest that chamnamul may be useful in prevention of hyperglycemia and reduction of oxidative stress in mice fed a HFHS diet.
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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Superóxido Dismutase / Tiobarbitúricos / Glicemia / Resistência à Insulina / Peroxidação de Lipídeos / Catalase / Colesterol / Substâncias Reativas com Ácido Tiobarbitúrico / Estresse Oxidativo / Acarbose Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Nutrition Research and Practice Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Superóxido Dismutase / Tiobarbitúricos / Glicemia / Resistência à Insulina / Peroxidação de Lipídeos / Catalase / Colesterol / Substâncias Reativas com Ácido Tiobarbitúrico / Estresse Oxidativo / Acarbose Tipo de estudo: Estudo prognóstico Limite: Animais / Humanos / Masculino Idioma: Inglês Revista: Nutrition Research and Practice Ano de publicação: 2013 Tipo de documento: Artigo