Expressions of E2F4 and E2F2 Transcription Factors in Breast Carcinoma
Korean Journal of Pathology
; : 301-306, 2005.
Article
em Ko
| WPRIM
| ID: wpr-181742
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: The E2F family (E2F1 to E2F6) of transcription factors plays a key role in cell cycle progression. Some act as oncogenes and others act as tumor suppressor genes (TSG) in a tissue-specific manner. E2F4 may function as a TSG. However, the role of E2F4 in breast carcinogenesis remains controversial. Also the clinical impact of E2F2 expression on breast cancer remains unknown. METHODS: Expressions of E2F4 and E2F2 were assessed immunohistochemically in 113 breast carcinomas and were compared with clinicopathological variables, expressions of G1/S checkpoint proteins (p16, cyclin D1 and Rb), and DNA ploidy to identify their possible role and to assess their prognostic value in breast cancer. RESULTS: Expressions of E2F4 and E2F2 were detected in 48 cases (42.5%) and 66 cases (58.4%), respectively. Expressions of E2F4 and E2F2 were significantly correlated with large tumor size (p<0.001) and lymph node metastasis (p<0.001). There was no correlation between expressions of E2F4 or E2F2 and any other variables, including age, histologic grade, DNA ploidy and expressions of p16, cyclin D1 and Rb. CONCLUSIONS: These results suggest that expressions of E2F4 and E2F2 are associated with growth and spread of breast cancer and indicate poor prognosis.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oncogenes
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Ploidias
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Prognóstico
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Fatores de Transcrição
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Mama
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Neoplasias da Mama
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DNA
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Imuno-Histoquímica
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Ciclo Celular
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Genes Supressores de Tumor
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Pathology
Ano de publicação:
2005
Tipo de documento:
Article