The Effect of Platelet Derived Growth Factor on the Myocardial Revascularization in Implantation of Rabbit Internal Mammary Artery / 대한흉부외과학회지
The Korean Journal of Thoracic and Cardiovascular Surgery
;
: 277-284, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-182067
ABSTRACT
BACKGROUND:
Coronary artery bypases grafting in the old aged is associated with high mortality and morbidity, and it is difficult to perform if the coronary artery is diffusely disease. Recently it has been known that platelet derived growth factor(PDGF), especially PDGF-BB, stimulates angiogenesis. MATERIAL ANDMETHOD:
New Zealand white rabbit were used. In an attempt to achieve effevtive cardiac revasculatrization without vascular anastmosis, we divided into three groups(group I Left anterior descending artery(LAD) was occluded by ligature, group II Bilateral internal mammary vascular pedicles were dissected and implanted into myocardium, group III The vascular pedicles were implanted into myocardium and PDGF-BB was injected into the myocardial tissue). Two weeks after IMA implantation, the proximal region of implanted LAD was ligated. Four days after LAD ligation angiogram, triphenyl tetrazolium chloride(TTD) staining and hematoxylin eosin staining were performed.RESULT:
1. Survival rate in group II was significantly higher than that in group I (P<0.05), and survival rate in group III was signficantly higher than that in group II(53% vs 93%, P<0.01). 2. There were significant differences in the ratio of area of necrosis to area at risk between group I and group II, and between group II and group III (P<0.01). 3. Microangiogram for angiogenic response revealed wide area of extensive revascularization with patent vessels in group III. 4. Histologic findings of three groups showed that polymorphonuclear leukocyte infiltration was minimal in group II and none in group III.CONCLUSIONS:
PDGF-BB can establish functinal cardiac revasculatization through systemic vessels implanted directly into the myocardium.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plaquetas
/
Fator de Crescimento Derivado de Plaquetas
/
Ponte de Artéria Coronária
/
Taxa de Sobrevida
/
Mortalidade
/
Amarelo de Eosina-(YS)
/
Vasos Coronários
/
Transplantes
/
Hematoxilina
/
Ligadura
Tipo de estudo:
Estudo prognóstico
País/Região como assunto:
Oceania
Idioma:
Coreano
Revista:
The Korean Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
2000
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS