NF-kappaB and CREB Are Involved in IL-8 Production of Human Neutrophils Induced by Trichomonas vaginalis-Derived Secretory Products
The Korean Journal of Parasitology
;
: 291-294, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-182102
ABSTRACT
Trichomonas vaginalis is a flagellated lumen-dwelling extracellular protozoan parasite that causes human trichomoniasis via sexual intercourse. Human neutrophils play a crucial role in acute tissue inflammatory responses in T. vaginalis infection. In this study, we investigated the signaling mechanism of neutrophil responses when stimulated with T. vaginalis-derived secretory products (TvSP), which were collected from 1x10(7) live trichomonads. Incubation of human neutrophils isolated from peripheral blood with TvSP induced up-regulation of IL-8 protein secretion. In addition, stimulation with TvSP induced phosphorylation of NF-kappaB and CREB in neutrophils. Moreover, TvSP-induced IL-8 production was also significantly inhibited by pretreatment of neutrophils with ikappaB inhibitor or CREB inhibitor. These results suggest that transcription factors NF-kappaB and CREB are involved in IL-8 production in human neutrophils induced by stimulation with T. vaginalis infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fosforilação
/
Trichomonas vaginalis
/
Interleucina-8
/
NF-kappa B
/
Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico
/
Experimentação Humana
/
Neutrófilos
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
The Korean Journal of Parasitology
Ano de publicação:
2011
Tipo de documento:
Artigo
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