Pathogenesis and Treatment of Intestinal Behcet's Disease / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 3-8, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-182232
ABSTRACT
Intestinal Behcet's disease (BD) refers to colonic ulcerative lesions documented by objective measures in patients with BD. Although the causes of intestinal BD are unknown, genetic, environmental, and immunological factors have been suggested. Intestinal BD is common in BD patients from Far East, while it is uncommon in those from the Middle East. The reasons for such peculiar geographic distribution in intestinal BD are unknown, but may provide clues for the elucidation of putative etiological agents or genetic factors that might be associated with intestinal BD. Although the treatment of Crohn's disease has improved significantly during past decade, the treatment of intestinal BD is still problematic. Corticosteroids, sulfasalazine, immunomodulators, and colchicines have been used to treat intestinal BD with varying degree of success. Thalidomide and its analogues also appear to be applicable. Monoclonal antibodies to TNF-alpha have recently been focused as a novel therapeutic option for patients with intestinal BD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Sulfassalazina
/
Talidomida
/
Colite Ulcerativa
/
Doença de Crohn
/
Colchicina
/
Síndrome de Behçet
/
Fator de Necrose Tumoral alfa
/
Corticosteroides
/
Fatores Imunológicos
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Gastroenterology
Ano de publicação:
2007
Tipo de documento:
Artigo
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