The Rate of Drug-Resistant Tuberculosis in Korean Children and Adolescents Since 2007
Journal of Korean Medical Science
;
: 954-960, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-182398
ABSTRACT
The incidence of drug-resistant tuberculosis (DR-TB) in pediatric populations is a critical indicator of national TB management and treatment strategies. Limited data exist regarding the rate of pediatric DR-TB. In this study, we aimed to analyze the status of DR-TB in Korean children from 2007 to 2013. We analyzed specimens submitted to the Korean Institute of Tuberculosis using Mycobacterium tuberculosis culture and drug susceptibility tests (DSTs) from January 2007 through December 2013. Specimens from patients ≤ 19 years of age were included. Among the 2,690 cases, 297 cases were excluded because of insufficient data, leaving 2,393 cases for the final analysis. In total, resistance to one or more TB drugs was 13.5%. The resistance rates of each of the drugs were as follows isoniazid (INH) 10.2%, rifampin (RFP) 5.1%, ethambutol (EMB) 3.7%, and pyrazinamide (PZA) 3.1%. The resistance rate of multidrug-resistant TB (MDR-TB) was 4.2%, and that of extensively drug-resistant TB (XDR-TB) was 0.8%. The overall drug resistance rate demonstrated significant increase throughout the study period (P 15 years (P < 0.001). The drug resistance rate has increased throughout the study period.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pirazinamida
/
Rifampina
/
Tuberculose
/
Resistência a Medicamentos
/
Incidência
/
Tuberculose Resistente a Múltiplos Medicamentos
/
Etambutol
/
Isoniazida
/
Mycobacterium tuberculosis
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2017
Tipo de documento:
Artigo
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