Langerhans Cell Histiocytosis That Improved with Oral Isotretinoin Therapy / 대한피부과학회지
Korean Journal of Dermatology
;
: 893-897, 2010.
Artigo
em Coreano
| WPRIM
| ID: wpr-182727
ABSTRACT
Langerhans cell histiocytosis (LCH) is a reactive disease in which abnormal Langerhans cells accumulate in various body sites. We report here on a 51-year-old male patient with LCH that was classified as single-system disease (restricted LCH). The skin lesions were a small, deep ulcer in the right inguinal area and multiple erythematous papules scattered on the lower abdomen, and the patient had these lesions for 1 year. The histopathologic examination revealed a dense histiocytic infiltration in the dermis, and most of the cells showed the characteristics of "LCH" cells. The immunohistochemistry for S-100 protein and CD1a complex all showed positive results. The patient was much improved after surgical excision of the inguinal ulcer and administering oral isotretinoin (20 mg daily) for 8 months, and there was no recurrence. We think retinoid is an effective treatment option for LCH, especially for single system disease.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Pele
/
Úlcera
/
Imuno-Histoquímica
/
Isotretinoína
/
Proteínas S100
/
Células de Langerhans
/
Histiocitose de Células de Langerhans
/
Derme
/
Abdome
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2010
Tipo de documento:
Artigo
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