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Prognostic Significance of Fascin Expression in Stage I Non-small Cell Lung Cancer / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases ; : 105-109, 2008.
Artigo em Coreano | WPRIM | ID: wpr-182750
ABSTRACT

BACKGROUND:

Fascin is an actin-bundling protein that plays an important role in cellular motility. Fascin is normally expressed in the neuronal and mesenchymal cells and its expression is low or absent in the epithelia. However, an overexpression of fascin has been linked to the invasive behavior of some neoplasms such as breast, stomach and ovarian tumors. In this study, we evaluated the expression of fascin and its prognostic significance in stage I non-small cell lung cancer (NSCLC).

METHODS:

Immunohistochemical staining for fascin was performed on the paraffin-embeded tissue sections of 81 cases of resected NSCLC. Staining of more than 5% of the tumor cells was recorded as positive immunoreactivity.

RESULTS:

Fascin expression was seen in 73% (59/81) of the cases and this was more frequently seen in squamous cell carcinoma than in adenocarcinoma (93% vs 42%). There were no significant correlations of fascin immunoreactivity with tumor recurrence and overall survival.

CONCLUSION:

The expression rate of fascin was relatively high in NSCLC, but this was without prognostic significance. The exact clinical role of fascin should be defined through further investigations.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Recidiva / Estômago / Mama / Carcinoma de Células Escamosas / Adenocarcinoma / Proteínas de Transporte / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Proteínas dos Microfilamentos Tipo de estudo: Estudo prognóstico Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Prognóstico / Recidiva / Estômago / Mama / Carcinoma de Células Escamosas / Adenocarcinoma / Proteínas de Transporte / Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares / Proteínas dos Microfilamentos Tipo de estudo: Estudo prognóstico Idioma: Coreano Revista: Tuberculosis and Respiratory Diseases Ano de publicação: 2008 Tipo de documento: Artigo