Optimization of Extraction Condition of Hesperidin in Citrus unshiu Peels using Response Surface Methodology
Natural Product Sciences
;
: 141-145, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-182828
ABSTRACT
Hesperidin, which is the most abundant flavonoid of Citrus unshiu (Rutaceae), has been reported to possess diverse activities and widely used as functional foods and cosmetics. For the development of functional products, extraction procedure is indispensable. Extraction conditions affect the composition of extract as well as its biological activity. Therefore, we tried to optimize extraction conditions such as extraction solvent, extraction time and extraction temperature for maximum yield of hesperidin using response surface methodology with threelevel-three-factor Box-Behnken design (BBD). Regression analysis showed a good fit of the experimental data and the optimal condition was obtained as ethanol concentration, 59.0%; temperature 71.5degrees C and extraction time, 12.4 h. The hesperidin yield under the optimal condition was found to be 287.8 microg per 5 mg extract, which was well matched with the predicted value of 290.5 microg. These results provides optimized extraction condition for hesperidin and might be useful for the development of hesperidin as functional products like health supplements, cosmetics and medicinal products.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Citrus
/
Etanol
/
Alimento Funcional
/
Hesperidina
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2015
Tipo de documento:
Artigo
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