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Thromboelastographic Evaluation of Coagulation in Patients With Liver Disease
Annals of Laboratory Medicine ; : 204-212, 2017.
Artigo em Inglês | WPRIM | ID: wpr-183526
ABSTRACT

BACKGROUND:

The aims of this study were to investigate the parameters of thromboelastography (TEG) for evaluating coagulopathy and to reveal an association with disease severity and/or transfusion requirement in patients with chronic liver disease (CLD) in a clinical laboratory setting.

METHODS:

We enrolled two groups of adult patients with cirrhotic (N=123) and non-cirrhotic liver disease (N=52), as well as 84 healthy controls. Reaction time (R), kinetic time (K), α-angle (α), maximal amplitude (MA), and coagulation index (CI) were measured with kaolin-activated citrated blood with the TEG 5000 system (Haemonetics Corporation, USA). Platelet count, prothrombin time international normalized ratio (PT INR), albumin, bilirubin, and creatinine were simultaneously measured. The CLD severity was calculated by using the Child-Pugh (C-P) and Model for End-stage Liver Disease (MELD) scores. Transfusion history was also reviewed.

RESULTS:

All TEG parameters, PT INR, and platelet count in the cirrhotic group showed significant differences from those in other groups. At least one or more abnormal TEG parameters were identified in 17.3% and 44.7% of patients in the non-cirrhotic and cirrhotic group, respectively. Patients with cirrhotic disease had hypocoagulability. A weak correlation between R and PT INR (r=0.173) was noted. The TEG parameters could not predict CLD severity using the C-P and MELD scores. Patients with normal TEG parameters did not receive transfusion.

CONCLUSIONS:

Clinical application of TEG measurements in CLD can be informative for investigating coagulopathy or predicting the risk of bleeding. Further studies are warranted.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Contagem de Plaquetas / Tempo de Protrombina / Tempo de Reação / Tromboelastografia / Bilirrubina / Coeficiente Internacional Normatizado / Creatinina / Hemorragia / Fígado / Hepatopatias Tipo de estudo: Estudo prognóstico Limite: Adulto / Humanos Idioma: Inglês Revista: Annals of Laboratory Medicine Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Contagem de Plaquetas / Tempo de Protrombina / Tempo de Reação / Tromboelastografia / Bilirrubina / Coeficiente Internacional Normatizado / Creatinina / Hemorragia / Fígado / Hepatopatias Tipo de estudo: Estudo prognóstico Limite: Adulto / Humanos Idioma: Inglês Revista: Annals of Laboratory Medicine Ano de publicação: 2017 Tipo de documento: Artigo