The immunogenicity and reactogenicity of Td booster vaccination in Korean preadolescents, aged with 11-12 years old / 소아과
Korean Journal of Pediatrics
;
: 1185-1190, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-18367
ABSTRACT
PURPOSE:
This study was undertaken to evaluate the immunogenicity and reactogenicity of Td booster immunization in early preadolescents of Korea.METHODS:
Healthy preadolescents, who had been vaccinated with 4 or 5 doses of DTaP vaccines until 6 years old age, were enrolled in this study from August 2006 to April 2007 . Diphtheria and tetanus anti-toxoid antibodies in sera were measured by ELISA just before vaccination and 4 weeks after vaccination to evaluate immunogenicity. Local and systemic adverse reactions observed for 4 weeks after vaccination to access reactogenicity.RESULTS:
183 preadolescents were enrolled and mean age was 11.40+/-0.51 years old. All subjects achieved seroprotective diphtheria and tetanus anti-toxoid antibodies (titers > or =0.1 IU/mL) after Td booster vaccination. Among 183 vaccinees, 73.8% showed local adverse reactions and 37.2% systemic adverse reactions. Pain at injection site (66.1%) was the most common local reaction, and the most commonly shown systemic reaction was myalgia (17.5%). The adverse reactions were spontaneously relieved within three days after vaccination.CONCLUSION:
Td vaccine in this study was high immunogenic and showed an acceptable tolerance in Korean preadolescents. Td booster vaccination at 11 -12 years old is the most effective method to increase compliance of the vaccination and to decrease the incidence of diphtheria and tetanus.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tétano
/
Ensaio de Imunoadsorção Enzimática
/
Incidência
/
Imunização Secundária
/
Imunização
/
Vacinação
/
Complacência (Medida de Distensibilidade)
/
Vacinas contra Difteria, Tétano e Coqueluche Acelular
/
Vacina contra Difteria e Tétano
/
Difteria
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Idoso
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2008
Tipo de documento:
Artigo
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