Psychiatric Disorder in Two Siblings with Hallervorden-Spatz Disease
Psychiatry Investigation
; : 226-229, 2009.
Article
em En
| WPRIM
| ID: wpr-183811
Biblioteca responsável:
WPRO
ABSTRACT
Hallervorden-Spatz disease (HSD) is a rare autosomal-recessive hereditary disorder characterized by the early onset of progressive movement alterations, including dystonia, rigidity, choreoathetosis, and mental deterioration. HSD is also associated with a variety of psychiatric symptoms, primarily depression and mental deterioration. However, psychosis has rarely been reported as a major symptom of HSD. We report two siblings who presented psychiatric symptoms as major clinical presentations, accompanied by ataxic and spastic gait, dysarthria, and typical neuroimaging findings of HSD. A 14-year-old girl presented complex motor tics, stereotypic behavior and anxiety symptoms. Her older brother, a 16-year-old boy, presented prominent auditory hallucinations, persecutory delusions and social withdrawal symptoms. Psychiatric symptoms were improved after atypical antipsychotic treatment. HSD is a rare disease but should be carefully considered in the diagnosis of patients with both motor disorder and various psychiatric symptoms.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Ansiedade
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Transtornos Psicóticos
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Síndrome de Abstinência a Substâncias
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Tiques
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Transtornos Neurológicos da Marcha
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Delusões
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Doenças Raras
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Irmãos
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Depressão
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Disartria
Limite:
Adolescent
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Humans
Idioma:
En
Revista:
Psychiatry Investigation
Ano de publicação:
2009
Tipo de documento:
Article