Application of aptamers for assessment of vaccine efficacy
Clinical and Experimental Vaccine Research
;
: 160-163, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-184068
ABSTRACT
Assessing antigen concentration of vaccine is essential step in determining the quality of the vaccine prior to vaccination. After vaccination, vaccine-induced antibody titer should also be measured to verify the vaccine efficacy. Since conventional assay used for vaccine concentrations and induced Ab-titers is antibody-based enzyme-linked immunosorbent assay, the assay inevitably brings drawbacks of antibody such as high cost for production, limited stability, and inconsistent quality between lot-to-lots. Aptamer is single-stranded nucleic acid having three-dimensional structure and has features overcoming limitations of antibody. This review will briefly introduce the features of aptamer and potential of aptamer-based system for evaluation of vaccine efficacy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ensaio de Imunoadsorção Enzimática
/
Vacinas
/
Vacinação
/
Anticorpos
Idioma:
Inglês
Revista:
Clinical and Experimental Vaccine Research
Ano de publicação:
2017
Tipo de documento:
Artigo
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