Animal models for dengue vaccine development and testing
Clinical and Experimental Vaccine Research
; : 104-110, 2017.
Article
em En
| WPRIM
| ID: wpr-184075
Biblioteca responsável:
WPRO
ABSTRACT
Dengue fever is a tropical endemic disease; however, because of climate change, it may become a problem in South Korea in the near future. Research on vaccines for dengue fever and outbreak preparedness are currently insufficient. In addition, because there are no appropriate animal models, controversial results from vaccine efficacy assessments and clinical trials have been reported. Therefore, to study the mechanism of dengue fever and test the immunogenicity of vaccines, an appropriate animal model is urgently needed. In addition to mouse models, more suitable models using animals that can be humanized will need to be constructed. In this report, we look at the current status of model animal construction and discuss which models require further development.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Mudança Climática
/
Vacinas
/
Doenças Endêmicas
/
Modelos Animais
/
Dengue
/
Vírus da Dengue
/
Coreia (Geográfico)
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Clinical and Experimental Vaccine Research
Ano de publicação:
2017
Tipo de documento:
Article