Mammary Carcinoma Arising in Microglandular Adenosis: A Report of Five Cases
Journal of Pathology and Translational Medicine
;
: 422-427, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-184095
ABSTRACT
Mammary carcinoma arising in microglandular adenosis (MGA) is extremely rare, and MGA is regarded as a non-obligate precursor of triple-negative breast cancer. We report five cases of carcinoma arising in MGA of the breast. All cases showed a spectrum of proliferative lesions ranging from MGA to atypical MGA, ductal carcinoma in situ or invasive carcinoma. Immunohistochemically, all cases were triple-negative and expression of S-100 protein gradually decreased as the lesions progressed from MGA to atypical MGA and carcinoma. Three cases showed acinic cell differentiation with reactivity to α1-antitrypsin, and one case was metaplastic carcinoma. During clinical follow-up, one patient developed local recurrence. Carcinoma arising in MGA is a rare but distinct subset of triple-negative breast cancer with characteristic histologic and immunohistochemical findings.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Mama
/
Proteínas S100
/
Seguimentos
/
Carcinoma Intraductal não Infiltrante
/
Células Acinares
/
Doença da Mama Fibrocística
/
Neoplasias de Mama Triplo Negativas
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Pathology and Translational Medicine
Ano de publicação:
2017
Tipo de documento:
Artigo
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