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Over-expression of MMP-3 in the fissured tissue of cleft lip and palate
Journal of the Korean Association of Oral and Maxillofacial Surgeons ; : 19-26, 2006.
Artigo em Inglês | WPRIM | ID: wpr-185046
ABSTRACT

OBJECTIVE:

In order to elucidate the retrogressive degeneration of orofacial cleft, the fissured tissues of prenatal and postnatal cleft lip and palate were examined by histological and immunohistochemical methods.

DESIGN:

Totally 42 cases of prenatal (n=17) and postnatal (n=25) cleft lip and/or palate were examined in comparison with 10 cases of normal lip and oral mucosa using immunohistochemical stainings of MMP-3, MMP-9, MMP-10, cathepsin G, PCNA, E-cadherin, TGase 2, HSP-70, vWF, and VEGF. MAIN OUTCOME

MEASURES:

In the fissured tissue the sebaceous glands were strongly positive for PCNA and grew into the underlying fibromuscular tissue (24/42). Some hyperplastic sebaceous glands of prenatal cleft lip produced infundibular follicular cyst (9/17). The skin and mucosal epithelia from the postnatal cleft lip and palate (10/25) showed severe basal hyperplasia (11/25) and melanocyte infiltration (7/25).

RESULTS:

The immunostaining of MMP-3 and HSP-70 were strongly positive in the hyperplastic sebaceous glands and nearby atrophying muscle bundles of the fissured tissue, while MMP-9, MMP-10, and cathepsin G were almost negative. The immunoreactions of the other antibodies used in this study were similar between in the fissured tissues and in the normal controls.

CONCLUSIONS:

These data suggest that the over-expression of MMP-3 is closely related to the sebaceous gland hyperplasia, epithelial dysplasia, and the muscle degeneration, and that the over-expression of MMP-3 in the fissured tissue may continuously aggravate the cleft condition in the later life.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Palato / Glândulas Sebáceas / Pele / Cisto Folicular / Caderinas / Fenda Labial / Avaliação de Resultados em Cuidados de Saúde / Antígeno Nuclear de Célula em Proliferação / Fator A de Crescimento do Endotélio Vascular / Catepsina G Limite: Adulto / Humanos Idioma: Inglês Revista: Journal of the Korean Association of Oral and Maxillofacial Surgeons Ano de publicação: 2006 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Palato / Glândulas Sebáceas / Pele / Cisto Folicular / Caderinas / Fenda Labial / Avaliação de Resultados em Cuidados de Saúde / Antígeno Nuclear de Célula em Proliferação / Fator A de Crescimento do Endotélio Vascular / Catepsina G Limite: Adulto / Humanos Idioma: Inglês Revista: Journal of the Korean Association of Oral and Maxillofacial Surgeons Ano de publicação: 2006 Tipo de documento: Artigo