Genetic risk factors associated with respiratory distress syndrome / 소아과
Korean Journal of Pediatrics
;
: 157-163, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-185148
ABSTRACT
Respiratory distress syndrome (RDS) among preterm infants is typically due to a quantitative deficiency of pulmonary surfactant. Aside from the degree of prematurity, diverse environmental and genetic factors can affect the development of RDS. The variance of the risk of RDS in various races/ethnicities or monozygotic/dizygotic twins has suggested genetic influences on this disorder. So far, several specific mutations in genes encoding surfactant-associated molecules have confirmed this. Specific genetic variants contributing to the regulation of pulmonary development, its structure and function, or the inflammatory response could be candidate risk factors for the development of RDS. This review summarizes the background that suggests the genetic predisposition of RDS, the identified mutations, and candidate genetic polymorphisms of pulmonary surfactant proteins associated with RDS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Gêmeos
/
Surfactantes Pulmonares
/
Recém-Nascido Prematuro
/
Fatores de Risco
/
Predisposição Genética para Doença
/
Proteínas Associadas a Surfactantes Pulmonares
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
/
Recém-Nascido
Idioma:
Inglês
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2014
Tipo de documento:
Artigo
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