Lipid A as a Drug Target and Therapeutic Molecule
Biomolecules & Therapeutics
;
: 510-516, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-185234
ABSTRACT
In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vias Biossintéticas
/
Lipídeo A
Idioma:
Inglês
Revista:
Biomolecules & Therapeutics
Ano de publicação:
2015
Tipo de documento:
Artigo
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