Primary Central Nervous System Lymphoma Diagnosed by Biopsy of Skin and Sural Nerve

ABSTRACT

Primary central nervous system lymphoma (PCNSL) is a rare tumor that accounts for less than 2% of all cerebral neoplasms. A 72-year-old man had been suffering from recurrent cranial nerve palsies for several years. His condition improved with steroid treatment, but then eventually worsened; he developed encephalopathic symptoms, quadriparesis, axonal neuropathy, and skin lesions. He was eventually diagnosed with PCNSL following an examination of skin and sural nerve biopsy samples. Biopsy of skin lesions or nerves should be considered for the accurate and early diagnosis of PCNSL.